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A surface representation of human CD38, derived from the x-ray crystal structure and shown on a cell membrane      Published in the journal Structure (Vol. 13, Sept. 2005)  Cornell University researchers have discovered the 3-D crystal structure of a protein, human CD38, which may lead to important discoveries about how cells release calcium -- a mineral used in almost every cellular process. The findings also may offer insights into mechanisms involved in certain diseases, ranging from leukemia to diabetes and HIV-AIDS.

New high-precision x-ray camera design (shown in F2 station)

Microcrystallography at MacCHESS ...MacCHESS microcrystallography initiative is bringing a number of major improvements to our beamlines that will dramatically enhance data collection on tiny crystals... By Richard Gillilan

The National Institutes of Health (NIH), through its National Center for Research Resources (NCRR), funds MacCHESS for two purposes: core research and support of CHESS users, who perform macromolecular diffraction experiments. MacCHESS staff conduct research in the areas of cell signaling, micro diffraction, membrane proteins, optimized data collection at synchrotron sources, crystallographic phasing, large unit cell crystallography, x-ray optics for crystallography and other areas relevant to macromolecular crystallography. On the user support front, the facility makes available specialized equipment and expertise, in addition to those provided by CHESS to all users. MacCHESS staff provide training and advice in the use of all these amenities. Guidance in determining MacCHESS's major emphases is provided by the MacCHESS Advisory Committee.

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