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Macromolecular X-ray science at the Cornell High Energy Synchrotron Source (MacCHESS) provides a facility for the utilization of both established and emerging technologies to advance the research goals of the biomedical research community. Work performed at MacCHESS yields fundamentally important insights into biology and biomedicine, adding to the understanding of complex membrane receptor-signaling systems, the regulation of ion channels in neuronal function, catalytic mechanisms of enzymes, and the complex macromolecular assemblies responsible for gene expression.

DNA to RNA - more ways than one

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Information encoded in our genes controls how we live and grow. As part of this complex process, DNA is transcribed to RNA, one "letter" (nucleotide) at a time, by an enzyme called RNA polymerase (RNAP). At a later stage, 3-nucleotide RNA sequences are translated into protein according to the genetic code.

A Pioneer of Scientific Tools

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“Most scientists focus on a very specific area, but I do many different things,” says Sol Gruner, Physics. “I’m a research mutt. Mainly, I develop tools to attack scientific problems people haven’t looked at yet, largely because the tools needed to solve those problems haven’t existed.”

RAW Power! MacCHESS software brings synchrotron-level data processing to the laptop and home laboratory

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Since its introduction by Søren Skou (Nielsen) in 2010, the BioXTAS RAW software has been a familiar interface to the many biomedical scientists collecting data at CHESS beamlines in recent years. From the start, RAW was designed specifically with novice users in mind: when scientists arrive at the beamline, they need something fast and easy to learn in the very limited time available … often late at night.

MacCHESS launches international data collection

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MacCHESS crossed a new threshold in June 2017 with international data collection. Normand Cyr collected data at CHESS beamline F1 remotely from the D'Avanzo lab at the University of Montreal in Quebec, Canada.

The 2017 CHESS Users’ Meeting and Science Workshops

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The 2017 CHESS Users' Meeting was held on Tuesday and Wednesday, June 6 - 7, 2017 in the Physical Sciences Building located on the Cornell University Ithaca campus. Like most years, the first day of the meeting covered facility-wide improvements and programs, a student paper prize, a poster session, tours and dinner banquet. The second day this year was special, however, hosting two science workshops as well as the annual meeting of the INCREASE organization.

Changing the identity of cellular enzyme spawns new pathway

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Integral membrane proteins, or IMPs, are a major class of proteins that play crucial roles in many cellular processes, including the catalysis of disulfide bonds, which are essential for the function and stability of many proteins such as antibodies, which have significant therapeutic potential.

CHESS Scheduled X-ray Run:

2017: November 1 - December 21
2018: February 7 - April 3
2018: April 11 - June 4

Proposal Submission

MacCHESS User Info

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MacCHESS provides a facility for developing new technology and for advancing the research goals of structural biologists as well as the broader biological research community.


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Microcrystallography refers to the ability to obtain useful structures from small (<30 μm) crystals...


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Small-Angle X-Ray Solution Scattering (SAXS) at MacCHESS. Protein envelope reconstruction...

BioSAXS Essentials training course


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Automounters are intended to help maximize throughput at synchrotron beam lines where heavy shielding and safety interlocks slow manual access to the experiment...

High Pressure cooling

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Having constructed and tested the necessary equipment at CHESS, pressure-cryocooling is available to the user community on an experimental basis

Take Control Of Every Plunge

NANUQ™ Cryocooling Technology

YouTube, Sep 6, 2016.

MiTeGen, LLC P.O. Box 3867 Ithaca, NY 14852
Phone: +1 877 MiTeGen (648-3436)