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The National Institutes of Health (NIH), through its National Institute of General Medical Sciences (NIGMS), funds MacCHESS for two purposes: core research as motivated by the important biomedical problems and support to all structural biologists making use of the CHESS facility for crystallographic and small-angle X-ray scattering experiments, as well as for novel experiments requiring special equipment and staff assistance not readily available at other synchrotron sources. Macromolecular Diffraction at the Cornell High Energy Synchrotron Source (MacCHESS) provides a facility for developing new technology and for advancing the research goals of structural biologists as well as the broader biological research community. MacCHESS has a strong commitment to training future leaders, who will be able to translate advances in synchrotron science and structural biology into valuable biomedical applications. Guidance in determining MacCHESS's major emphases is provided by the MacCHESS Advisory Committee.

Changing the identity of cellular enzyme spawns new pathway

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Integral membrane proteins, or IMPs, are a major class of proteins that play crucial roles in many cellular processes, including the catalysis of disulfide bonds, which are essential for the function and stability of many proteins such as antibodies, which have significant therapeutic potential.

BioSAXS Essentials 7 training course now complete!

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We have now completed our 7th BioSAXS Essentials training course! BioSAXS (Biological Small Angle X-ray Solution Scattering) is a highly popular technique for understanding the structure and behavior of biomolecules in solution, without the need for freezing or crystallization. BioSAXS Essentials is specifically designed as a short, just-the-essentials course for non-specialists wishing to collect and publish BioSAXS data for the first time.

The Big Pore Theory could cure chronic pain

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Cornell University researchers have produced for the first time an image of P2X7, a receptor associated with chronic pain. Visualizing the shape of the receptor has also allowed them to make a second groundbreaking discovery: They observed that five painkiller molecules they tested did not bind the receptor at the place they expected, which could explain why these painkillers lack efficacy in human patients.

Concentrating on concentrators: Students design and test novel microfluidic ultrafiltration system for biological samples at the beamline

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Biological solution scattering experiments are often the culmination of months, or even years of preparation. The seemingly mundane little droplets of liquid we put into the X-ray beam are rare bits and pieces of the machinery of life, painstakingly separated and purified from Nature’s unimaginably complex brew.

Structural insight into HIV reverse transcriptase

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Arnold and DeStefano collaborated to study the aptamer using structural biology. Not only did they manage to solve the structure of the RT-aptamer complex, they found that the new inhibitor bound so tightly to RT that it stabilizes the complex and helps it to form better crystals than were previously available.

CHESS Scheduled X-ray Run:

2017: November 1 - December 21

Proposal Submission

MacCHESS User Info

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MacCHESS provides a facility for developing new technology and for advancing the research goals of structural biologists as well as the broader biological research community.


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Microcrystallography refers to the ability to obtain useful structures from small (<30 μm) crystals...


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Small-Angle X-Ray Solution Scattering (SAXS) at MacCHESS. Protein envelope reconstruction...

BioSAXS Essentials training course


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Automounters are intended to help maximize throughput at synchrotron beam lines where heavy shielding and safety interlocks slow manual access to the experiment...

High Pressure cooling

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Having constructed and tested the necessary equipment at CHESS, pressure-cryocooling is available to the user community on an experimental basis

Take Control Of Every Plunge

NANUQ™ Cryocooling Technology

YouTube, Sep 6, 2016.

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Phone: +1 877 MiTeGen (648-3436)